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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIKFYVE
All Species:
12.12
Human Site:
S1181
Identified Species:
29.63
UniProt:
Q9Y2I7
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2I7
NP_055855.2
2098
237108
S1181
K
D
A
S
S
T
S
S
G
K
S
G
S
K
N
Chimpanzee
Pan troglodytes
XP_516057
2098
237088
S1181
K
D
A
S
S
T
S
S
G
K
S
G
S
K
N
Rhesus Macaque
Macaca mulatta
XP_001108540
2098
237142
S1181
K
D
A
S
S
T
S
S
G
K
S
G
S
K
N
Dog
Lupus familis
XP_536048
2100
237099
S1183
K
E
A
P
A
M
A
S
S
R
P
G
S
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1T6
2097
236858
G1180
K
D
A
S
C
T
S
G
G
K
S
G
N
K
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508087
1539
172614
D682
T
V
S
R
I
A
Q
D
M
L
L
E
H
G
I
Chicken
Gallus gallus
XP_421967
2112
239039
A1194
K
D
V
S
S
V
P
A
G
R
T
G
C
K
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96838
1809
204617
Q952
Y
K
D
A
L
D
P
Q
N
H
Q
R
L
P
V
Honey Bee
Apis mellifera
XP_393666
1986
224732
L1115
S
P
M
W
P
D
C
L
D
P
T
S
H
Q
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P34756
2278
257401
D1347
V
K
Y
F
G
Y
N
D
L
V
V
R
L
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.1
95.2
N.A.
93.5
N.A.
N.A.
53.9
86.2
N.A.
N.A.
N.A.
28.7
34.1
N.A.
N.A.
Protein Similarity:
100
99.9
99.4
97
N.A.
96.3
N.A.
N.A.
60.2
91.5
N.A.
N.A.
N.A.
46.1
53.5
N.A.
N.A.
P-Site Identity:
100
100
100
40
N.A.
73.3
N.A.
N.A.
0
46.6
N.A.
N.A.
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
100
100
66.6
N.A.
80
N.A.
N.A.
6.6
66.6
N.A.
N.A.
N.A.
6.6
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
50
10
10
10
10
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
0
10
0
0
0
0
0
10
0
0
% C
% Asp:
0
50
10
0
0
20
0
20
10
0
0
0
0
0
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
0
10
0
10
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
10
50
0
0
60
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
20
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
30
% I
% Lys:
60
20
0
0
0
0
0
0
0
40
0
0
0
60
0
% K
% Leu:
0
0
0
0
10
0
0
10
10
10
10
0
20
0
0
% L
% Met:
0
0
10
0
0
10
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
10
0
0
0
10
0
30
% N
% Pro:
0
10
0
10
10
0
20
0
0
10
10
0
0
10
0
% P
% Gln:
0
0
0
0
0
0
10
10
0
0
10
0
0
10
0
% Q
% Arg:
0
0
0
10
0
0
0
0
0
20
0
20
0
0
10
% R
% Ser:
10
0
10
50
40
0
40
40
10
0
40
10
40
0
0
% S
% Thr:
10
0
0
0
0
40
0
0
0
0
20
0
0
0
10
% T
% Val:
10
10
10
0
0
10
0
0
0
10
10
0
0
0
10
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
10
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _